- Product Details
Keywords
- Nobiletin
- 478-01-3
- Nobiletin 98%
Quick Details
- ProName: Nobiletin powder 40%-98% CAS 478-01-3
- CasNo: 478-01-3
- Molecular Formula: C21H22O8
- Appearance: Brown Powder
- Application: Herbal Extract
- DeliveryTime: 3days after we receive the payment
- PackAge: 1> 25kg: Packed with paper drum with d...
- Port: Shanghai, Tianjin or other China main ...
- ProductionCapacity: 1000 Kilogram/Month
- Purity: 10:1
- Storage: Cool and dry place
- Transportation: Air/Sea/Express
- LimitNum: 1 Kilogram
- Plant of Origin: Citrus Peels
- Testing Method: HPLC
- Product Ecification: 98%
- Heavy Metal: <0.01ppm
- Voluntary Standards: Factory Standard
- Brand Name:: XAZB
- Part:: Whole Herb
- Grade:: Food & Pharma Grade
- Extraction Type:: Solvent Extraction
- Shelf Life:: 2 Years
Superiority
Our Company
Xi'an ZB Biotech Co., Ltd is specialized in researching, producing and selling herbal extract and API powder, which are mainly used in nutraceutical, cosmetic, beverage and food additives etc.
Owing plant base, extracting and purifying in GMP workshop, concentrating on the quality and cost each link. That XAZB Biotech is aiming of benefiting the world with lowest price but best products.
We are keeping overcritical on the quality and persisting in the profession all the time. XAZB owns two standardized production workshops, advanced multifunction extractors and juice concentrate equipment, covering 12,000m2. annual dried material processed 950MT, monthly production ability 60MT. 32 scientists are in R&D team. We have strict QC standards and perfect quality guarantee system, GMP certified, also FDA, ISO9001 and Halal certified.
We also build an integrative marketing center in Xi'an city, China, involving in research, test, sale and service. With full qualification and exporting experience, our products are widely sold to more than 40 countries from Europe, America, Southeast Asia, Oceania and so on.
Advantage
1. High quality with competitive price:
We are manufacturer and we have 2 factories in China,we can provide excellent quality products with factory price.
2. Fast and safe delivery:
1) Parcels can be sent out within 3 days after payment. Tracking number is available.
2) Secure and discreet shipment. You have various choices of transportation methods.
3. We have clients throughout the world:
1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet your desire.
2) Market feedback and goods feedback are appreciated, meeting customers's requirement is our responsibility.
3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.
4. Exported areas: Europe , southeast Asia , the Middle East , Africa , South America and some other countries and areas.
5. We manufacture Herbal Extract and Active Pharmaceutical Ingredients products.
Business scope: Organic & Inorganic Chemicals , Pigments & Dye stuffs , Water treatment chemicals, Intermediates, Food & FEED additives and other.
Details
Chinese alias: Chuanpi Ting, Tangerine
English name: Nobiletin
English alias: Naringenine-7-rhamnosidoglucoside
Specification: 40%-98%
CAS Number: 478-01-3
Molecular formula: C21H22O8
Molecular weight: 402.39
Detection method: HPLC
Product Description:
Nobiletin is a flavonoid isolated from citrus peels. It is an O-methylated flavone that has the activity to rescue
bulbectomy-induced memory impairment.
Nobiletin was found to have anti-inflammatory and anti-tumor invasion, proliferation, and metastasis in vitro and in animal studies.Nobiletin was also found to potentially inhibit cartilage degradation.
Nobiletin was shown to augment AMPA receptor activity and long-term potentiation in cell culture. Synergistic chemopreventive effects of nobiletin and atorvastatin on colon carcinogenesis have been described.
Nobiletin seems to be a very noble phytochemical with many potential health benefits. The most studied properties of nobiletin are its anti-inflammatory and anti-cancer activities. Nobiletin also helps to lower cholesterol levels and some studies indicate that it may improve impaired memory loss and treat acne.
Anti-inflammatory
Numerous in-vivo and in-vitro studies have demonstrated the anti-inflammatory activity of nobiletin and its metabolites. Nobiletin acts directly as an antioxidant but also interferes with biological inflammatory processes. It inhibits the expression of genes involved in inflammation by blocking the binding of NF-kappaB with DNA. One study showed that nobiletin reduced airway inflammation of asthmatic rats. Treatment of skin cells with nobiletin also reduced inflammation caused by ultraviolet-B radiation.
Anti-cancer
The anti-cancer properties of nobiletin are supported by many scientific studies. Nobiletin act by its antiproliferation effect without being toxic to normal cells. Favourable results have been obtained on cancer cell lines of the liver, stomach, prostate and colon.
Cholesterol Lowering
A study with cultured macrophages demonstrated the cholesterol lowering and atherosclerosis inhibiting properties of nobiletin. Nobiletin also inhibits the formation of macrophage foam cells, macrophages loaded wit lipids, which build up on artery walls.
Memory Loss
One study on a mice model showed that nobiletin my help to improve memory loss. The brains of the mice were chirurgically altered to obtain models of Alzheimer disease. It is not known if nobiletin improves the condition of human Alzheimer patients.
Acne treatment
According to the studies, nobiletin inhibited sebum production on hamsters and inhibited the proliferation of sebocytes, the cells that form the sebaceous gland. This observation led the researchers to conclude that nobiletin could be used as a drug for acne treatment.
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