Our Company

Xi'an ZB Biotech Co., Ltd is specialized in researching, producing and selling herbal extract and API powder, which are mainly used in nutraceutical, cosmetic, beverage and food additives etc.
Owing plant base, extracting and purifying in GMP workshop, concentrating on the quality and cost each link. That XAZB Biotech is aiming of benefiting the world with lowest price but best products.

We are keeping overcritical on the quality and persisting in the profession all the time. XAZB owns two standardized production workshops, advanced multifunction extractors and juice concentrate equipment, covering 12,000m2. annual dried material processed 950MT, monthly production ability 60MT. 32 scientists are in R&D team. We have strict QC standards and perfect quality guarantee system, GMP certified, also FDA, ISO9001 and Halal certified. 

We also build an integrative marketing center in Xi'an city, China, involving in research, test, sale and service. With full qualification and exporting experience, our products are widely sold to more than 40 countries from Europe, America, Southeast Asia, Oceania and so on

Advantage

1. High quality with competitive price:
We are manufacturer and we have 2 factories in China,we can provide excellent quality products with factory price.

2. Fast and safe delivery:
1) Parcels can be sent out within 3 days after payment. Tracking number is available.
2) Secure and discreet shipment. You have various choices of transportation methods.

3. We have clients throughout the world:
1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet your desire.
2) Market feedback and goods feedback are appreciated, meeting customers's requirement is our  responsibility.
3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.

4. Exported areas: Europe , southeast Asia , the Middle East , Africa , South America and some other countries and areas.
 
5. We manufacture Herbal Extract and Active Pharmaceutical Ingredients products.

Business scope: Organic & Inorganic Chemicals , Pigments & Dye stuffs , Water treatment chemicals, Intermediates, Food & FEED additives and other.

Product Name: Saxagliptin

CAS NO.:361442-04-8

M.F: C18H25N3O2

Introduction:

Saxagliptin is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs.This compound belongs to the class of organic compounds known as alpha amino acid amides. These are amide derivatives of alpha amino acids.

Post-administration of saxagliptin, GLP-1 and GIP levels rise up to 2- to 3- fold. Because it is very selective of DPP-4 inhibition, there are fewer systemic side effects. Saxagliptin inhibits DPP-4 enzyme activity for a 24-hour period. It also decreased glucagon concentrations and increased glucose-dependent insulin secretion from pancreatic beta cells. The half maximal inhibitory concentration (IC50) is 0.5 nmol/L. Saxagliptin did not prolong the QTc interval to a clinically significant degree.

Function&Application

Saxagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor antidiabetic for the treatment of type 2 diabetes. DPP-4 inhibitors are a class of compounds that work by affecting the action of natural hormones in the body called incretins. Incretins decrease blood sugar by increasing consumption of sugar by the body, mainly through increasing insulin production in the pancreas, and by reducing production of sugar by the liver. [Bristol-Myers Squibb Press Release] DPP-4 is a membrane associated peptidase which is found in many tissues, lymphocytes and plasma. DPP-4 has two main mechanisms of action, an enzymatic function and another mechanism where DPP-4 binds adenosine deaminase, which conveys intracellular signals via dimerization when activated. Saxagliptin forms a reversible, histidine-assisted covalent bond between its nitrile group and the S630 hydroxyl oxygen on DPP-4. The inhibition of DPP-4 increases levels active of glucagon like peptide 1 (GLP-1), which inhibits glucagon production from pancreatic alpha cells and increases production of insulin from pancreatic beta cells.

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