High Purity N-Acetylneuraminic acid/Sialic Acid/NANA CAS131-48-6 CAS NO.131-48-6

Xi'an ZB Biotech Co., Ltd is specialized in researching, producing and selling herbal extract and API powder, which are mainly used in nutraceutical, cosmetic, beverage and food additives etc.

Owing plant base, extracting and purifying in GMP workshop, concentrating on the quality and cost each link. That XAZB Biotech is aiming of benefiting the world with lowest price but best products.

We are keeping overcritical on the quality and persisting in the profession all the time. XAZB owns two standardized production workshops, advanced multifunction extractors and juice concentrate equipment, covering 12,000m2. annual dried material processed 950MT, monthly production ability 60MT. 32 scientists are in R&D team. We have strict QC standards and perfect quality guarantee system, GMP certified, also FDA, ISO9001 and Halal certified. 

We also build an integrative marketing center in Xi'an city, China, involving in research, test, sale and service. With full qualification and exporting experience, our products are widely sold to more than 40 countries from Europe, America, Southeast Asia, Oceania and so on

N-acetylneuraminic acid is the most widely distributed sialic acid (N-acylneuraminic acid) in nature, mainly composed of glycoproteins, glycolipids or bacterial capsular substances in animal cell membranes or secretions. In glycoprotein or glycolipid, because the 2-position ketone forms a glycosidic bond, it is located at the non-reducing end of the sugar side chain, and its negative charge or unique chemical structure makes it have various physiological specificities. In nature, from viruses to animals, the enzyme (neuraminidase) that hydrolyzes and removes the terminal N-acetylneuraminic acid is very widely distributed. By processing the change in the physiological activity of this enzyme, the terminal acidic sugar has been clarified. The role of residues. For example, this sugar residue constitutes the binding site of the influenza virus on the red blood cell membrane and plays a major role in the mutual recognition mechanism of plasma glycoproteins and liver cells or in the recognition mechanism of lymphocytes to the circulation pathway. Although the biosynthetic pathway is somewhat different in animals and bacteria, they all go through N-acetylmannosamine or its 6-phosphate, which is catalyzed by specific pyrophosphatase and reacts with CTP to generate CMP-N-acetylneuraminic acid Afterwards, sugar chains are incorporated by a glycosylation reaction.

1. Substrates of N-acetylneuraminic acid aldolase
2. Sialic acid is a carbohydrate that widely exists in nature and is also a basic component of many glycoproteins, glycopeptides and glycolipids. It has a wide range of biological functions, such as the regulation of the half-life of blood proteins, the neutralization of various toxins, the Adhesion, immune antigen-antibody responses, and protection against cytolysis. Biochemical derivatives of sialic acid are also commonly used in the synthesis of drugs.